Prednisone modestly decreases AUC of metronidazole
Clinical evidence,mechanism, importance and management
In 6 patients with Crohn’s disease AUC of metronidazole 250mg twice daily was reduced by 31 % by prednisone 10mg twice daily for 6 days, probably because prednisone induces metabolism of metronidazole by liver enzymes (See reference number 1).
Information appears to be limited to this report and interaction is probably of only limited clinical importance
1. Eradiri O,Jamali F, Thomson ABR. Interaction of metronidazole with phenobarbital, cimetidine, prednisone, and sulfasalazine in Crohn’s disease. Biopharm Drug Dispos (1988) 9, 219–
27.