Food reduces maximum plasma levels of loracarbef, but doesnot alter its bioavailability.
Clinical evidence,mechanism, importance and management
Loracarbef 400mg was given to 12 healthy subjects either in a fasting state or following a standard breakfast. Food slowed rate of absorption, but not total bioavailability of loracarbef (See reference number 1). In another study food was found to decrease maximum plasma levels of a single 200mg dose of loracarbef and increase time to achieve maximum levels but AUC of loracarbef was not significantly affected by food (See reference number 2). Loracarbef should be taken 1 hour before or 2 hrs after food (See reference number 3).
Roller S,Lode H, Stelzer I, Deppermann KM, Boeckh M, Koeppe P. Pharmacokinetics of loracarbef and interaction with acetylcysteine. Eur J Clin Microbiol Infect Dis (1992) 11, 851–5.
DeSante KA,Zeckel ML. Pharmacokinetic profile of loracarbef. Am J Med (1992) 92 (Suppl 6A), 16S–19S.
Lorabid (Loracarbef). Monarch Pharmaceuticals,Inc. US Prescribing information, September2002.