Clinical evidence,mechanism, importance and management
As part of a larger study, 6 HIV-positive subjects received atovaquone 500mg once daily, co-trimoxazole 960mg (trimethoprim/sulfamethoxazole 160/800 mg) twice daily, or combination, taken with food. There was no change in steady-state atovaquone levels but there was a minor 17 % decrease in steady-state trimethoprim levels and a minor 8 % decrease in sulfamethoxazole levels when both drugs were given together (See reference number 1).
1. Falloon J,Sargent S, Piscitelli SC, Bechtel C, LaFon SW, Sadler B, Walker RE, Kovacs JA,Polis MA, Davey RT, Lan HC, Masur H. Atovaquone suspension in HIV-infected volunteers:pharmacokinetics, pharmacodynamics, and TMP-SMX interaction study. Pharmacotherapy (1999) 19, 1050–6.