Clinical evidence,mechanism, importance and management
In a steady-state study,23 healthy subjects were given modafinil 200mg daily for 7 days, followed by 400mg daily for 3 weeks. During last week, 10 of subjects were also given dexamfetamine 20mg daily, 7 hrs after their modafinil dose. Dexamfetamine caused no significant change in pharmacokinetics of modafinil and combination was well tolerated. In addition, pharmacokinetics of dexamfetamine did not appear to be affected by modafinil, when compared with values reported in literature (See reference number 1). Similar results were found in a single dose study (See reference number 2). No additional precautions appear to be necessary on concurrent use.
Hellriegel ET,Arora S, Nelson M, Robertson P. Steady-state pharmacokinetics and tolerabilityof modafinil administered alone or in combination with dextroamphetamine in healthy volunteers. J Clin Pharmacol (2002) 42, 448–58.
Wong YN,Wang L, Hartman L, Simcoe D, Chen Y, Laughton W, Eldon R, Markland C, Grebow P. Comparison of the single-dose pharmacokinetics and tolerability of modafinil and dextroamphetamine administered alone or in combination in healthy male volunteers. J Clin Pharmacol (1998) 38, 971–8.