NSAIDs; Ibuprofen + Moclobemide - Drug Interactions

Moclobemide did not alter pharmacokinetics of ibuprofen, oribuprofen-induced faecal blood loss in one study. Ibuprofen doesnot affect pharmacokinetics of moclobemide.

Clinical evidence,mechanism, importance and management

A study in 24 healthy subjects found that moclobemide 150mg three times daily for 7 days had no effect on steady-state pharmacokinetics of ibuprofen 600mg three times daily, and amount of ibuprofen-induced faecal blood loss was unaffected (See reference number 1). Ibuprofen did not affect pharmacokinetics of moclobemide. No special precautions appear to be required during concurrent use.

1. Güntert TW,Schmitt M, Dingemanse J, Jonkman JHG. Influence of moclobemide on ibuprofen-induced faecal blood loss. Psychopharmacology (Berl) (1992) 106, S40–S42.