Bupropion + Corticosteroids - Drug Interactions

Clinical evidence,mechanism, importance and management

A case report describes a patient taking bupropion,who experienced a severe, prolonged seizure 24 hrs after receiving methylprednisolone 30mg for subacromial bursitis (See reference number 1). The author notes that there could be a risk of seizures in patients taking bupropion who are given prophylactic oral steroids (See reference number 1). This is in line with manufacturers’ suggestion that systemic steroids could increase risk of seizures, see Bupropion + Miscellaneous interaction.

1. White P. Interaction of intra-articular steroids and bupropion. Clin Radiol (2002) 57,235.