Theophylline + Nefazodone - Drug Interactions

Clinical evidence,mechanism, importance and management

Nefazodone 200mg twice daily for 7 days had no effect on pharmacokinetics or pharmacodynamics of theophylline 600mg to 1.2 g daily in patients with chronic obstructive airways disease,nor was there any effect on their FEV1 values (See reference number 1). No special precautions would seem necessary if both drugs are used.

1. Dockens RC,Rapoport D, Roberts D, Greene DS, Barbhaiya RH. Lack of an effect of nefazodone on the pharmacokinetics and pharmacodynamics of theophylline during concurrent administration in patients with chronic obstructive airways disease. Br J Clin Pharmacol (1995)40, 598–601.