The salicylate levels of a patient taking aspirin rose when levamisole was given,but this effect was not confirmed in a subsequentcontrolled study.
Clinical evidence,mechanism, importance and management
A preliminary report of a patient who had an increase in salicylate levels when levamisole was given with aspirin(See reference number 1) prompted a study in 9 healthy subjects of this possible interaction. Sustained-release aspirin 3.9 g daily in two divided doses was given over a period of 3 weeks,with levamisole 50mg three times a day for a week, each subject acting as his own control. No significant changes in plasma salicylate levels were found (See reference number 2).
Laidlaw D’A. Rheumatoid arthritis improved by treatment with levamisole and L-histidine.Med J Aust (1976) 2,382–5.
Rumble RH,Brooks PM, Roberts MS. Interaction between levamisole and aspirin in man. Br J Clin Pharmacol (1979) 7, 631–3.