Lithium + Antidepressants; Mirtazapine - Drug Interactions

Clinical evidence,mechanism, importance and management

In a randomised,double-blind, crossover study, 12 healthy subjects were given lithium carbonate 600mg daily or placebo for 10 days, with a single 30mg dose of mirtazapine on day 10. The pharmacokinetics of both mirtazapine and lithium were unaltered by concurrent use. In addition,no pharmacodynamic changes, as studied by psychometric testing, were identified (See reference number 1).

1. Sitsen JMA,Voortman G, Timmer CJ. Pharmacokinetics of mirtazapine and lithium in healthymale subjects. J Psychopharmacol (2000) 14, 172–6.