Clinical evidence,mechanism, importance and management
Ten heart transplant patients taking ciclosporin,azathioprine and diltiazem were also given clodronate 800mg daily for one week. No statistically significant differences were seen in their ciclosporin blood levels or AUCs while they were taking clodronate. Three of them were also taking simvastatin,two were taking ranitidine and one was taking propafenone, furosemide and cyclophosphamide. There would seem to be no reason for avoiding concurrent use, but authors of report suggest that longer-term use of clodronate should be well monitored (See reference number 1). There seems to be no information about other bisphosphonates.
1. Baraldo M,Furlanut M, Puricelli C. No effect of clodronate on cyclosporin A blood levels inheart transplant patients simultaneously treated with diltiazem and azathioprine. Ther DrugMonit (1994) 16, 435.