Urapidil does not appear to affect pharmacokinetics of digoxin
Clinical evidence,mechanism, importance and management
In 12 healthy subjects urapidil 60mg twice daily on days 5 to 8 had no significant effects on serum levels of digoxin 250 micrograms twice daily on day one, then 250 micrograms daily on days 2 to 8. Blood pressures and pulse rates were not significantly changed (See reference number 1). No special precautions seem necessary if both drugs are given.
1. Solleder P,Haerlin R, Wurst W, Klingmann I, Mosberg H. Effect of urapidil on steady-stateserum digoxin concentration in healthy subjects. Eur J Clin Pharmacol (1989) 37, 193–4.