Guanadrel did not affect pharmacokinetics of a single dose ofdigoxin
Clinical evidence,mechanism, importance and management
In 13 healthy subjects guanadrel 10mg orally every 12 hrs for 8 days did not affect pharmacokinetics of a single intravenous dose of digoxin given on day 5. One subject experienced a 10-minute episode of asymptomatic second-degree heart block (Wenckebach) 3 hrs after dose of digoxin, but reason for this effect was not clear (See reference number 1). There seem to be no reports of adverse interactions between digitalis glycosides and any of guanethidine-like antihypertensive drugs.
1. Wright CE,Andreadis NA. Digoxin pharmacokinetics when administered concurrently withguanadrel sulfate. Drug Intell Clin Pharm (1986) 20, 465.