Clinical evidence,mechanism, importance and management
A placebo-controlled, crossover study in 12 healthy subjects found that pharmacokinetics of steady-state digoxin 375 micrograms daily were not affected by an infusion of argatroban 2 micrograms/kg per minute for 120 hours. Steady-state argatroban levels were obtained within 3 hrs and maintained throughout infusion. Dosage adjustments should not be necessary during concurrent use (See reference number 1).
1. Inglis AML,Sheth SB, Hursting MJ, Tenero DM, Graham AM, DiCicco RA. Investigation ofthe interaction between argatroban and acetaminophen, lidocaine, or digoxin. Am J Health-Syst Pharm (2002) 59, 1258–66.