The mean procaine half-life in 6 healthy subjects was increased by66% (from 1.46 to 2.43 minutes) 2 hrs after they were givenacetazolamide 250mg orally. This appears to be because hydrolysis of procaine is inhibited by acetazolamide.(See reference number 1) As evidence of this interaction is limited to one report, its general significance is unclear.
1. Calvo R,Carlos R, Erill S. Effects of disease and acetazolamide on procaine hydrolysis by redblood cell enzymes. Clin Pharmacol Ther (1980) 27, 179–83.