Chenodeoxycholic acid and ursodeoxycholic acid reduce bioavailability of nitrendipine
Clinical evidence,mechanism, importance and management
In a single-dose study,6 healthy subjects were given nitrendipine 10mg with or without either chenodeoxycholic acid 200mg or 600 mg, or ursodeoxycholic acid 50 mg. Ursodeoxycholic acid reduced peak plasma level and AUC of nitrendipine by 54 % and 75%, respectively. Chenodeoxycholic acid 200mg decreased peak plasma level and AUC of nitrendipine by about 20%, but 600mg dose reduced peak plasma level and AUC of nitrendipine by 54 % and 68%, respectively. The reduction in bioavailability of nitrendipine was possibly due to effects of bile acids on tablet disintegration or more probably on drug solubilisation. The clinical importance of interaction is not known (See reference number 1).
1. Sasaki M,Maeda A, Sakamoto K-I, Fujimura A. Effect of bile acids on absorption of nitrendipine in healthy subjects. Br J Clin Pharmacol (2001) 52, 699–701.