Clinical evidence,mechanism, importance and management
A study(See reference number 1) in a group of 9 women found that sedative effects of a single 5-micrograms/kg subcutaneous dose of apomorphine were decreased when they were taking a combined oral contraceptive (ethinylestradiol 30 micrograms, levonorgestrel 150 or 250 micrograms). The clinical importance of this is uncertain.
1. Chalmers JS,Fulli-Lemaire I, Cowen PJ. Effects of the contraceptive pill on sedative responsesto clonidine and apomorphine in normal women. Psychol Med (1985) 15, 363–7.