A retrospective analysis of studies in a total of 250 patients givenfluorouracil for treatment of gastrointestinal cancer foundthat chlorprothixene, cinnarizine, prochlorperazine, sodiumpentobarbital, thiethylperazine, trimethobenzamide (in antiemetic doses) did not significantly increase toxicity or decrease therapeutic effects, when compared with a placebo.(See reference number 1)
1. Moertel CG,Reitemeier RJ, Hahn RG. Effect of concomitant drug treatment on toxic and therapeutic activity of 5-fluorouracil (5-FU; NSC-19893). Cancer Chemother Rep (1972) 56, 245–
7.