Valproate + Theophylline - Drug Interactions

A study in 6 healthy subjects found that oral aminophylline200 mg every 6 hrs for 3 doses did not affect pharmacokinetics of a single 400mg dose of sodium valproate

1. Kulkarni C,Vaz J, David J, Joseph T. Aminophylline alters pharmacokinetics of carbamazepine but not that of sodium valproate — a single dose pharmacokinetic study in humanvolunteers. Indian J Physiol Pharmacol (1995) 39, 122–6.