Alcohol may possibly increase adverse effects of niclosamide
Clinical evidence,mechanism, importance and management
The manufacturer of niclosamide advises avoiding alcohol while taking niclosamide. The reasoning behind this is that while niclosamide is virtually insoluble in water, it is slightly soluble in alcohol, which might possibly increase its absorption by gut, resulting in an increase in its adverse effects. There are no formal reports of this but manufacturer says that they have some anecdotal information that is consistent with this suggestion (See reference number 1).
1. Bayer. Personal communication,July 1992.