Orlistat does not alter pharmacokinetics of phenytoin
Clinical evidence,mechanism, importance and management
In a placebo-controlled,randomised, crossover study, 12 healthy subjects were given a single 300mg dose of phenytoin on day 4 of a 7-day course of orlistat 120mg three times daily. The pharmacokinetics of phenytoin were unchanged by orlistat,(See reference number 1)and no special precautions are therefore thought to be needed if these two drugs are given concurrently.
1. Melia AT,Mulligan TE, Zhi J. The effect of orlistat on the pharmacokinetics of phenytoin inhealthy volunteers. J Clin Pharmacol (1996) 36, 654–8.